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Continuous Flow Synthesis of Cyclobutenes using LED technology

Cyclobutenes are highly strained ring systems of considerable synthetic interest that can be accessed via cycloaddition reactions between alkenes and alkynes. However, their traditional preparation relies on photochemical [2+2] cycloadditions that exploit low-wavelength UV radiation emitted from inefficient medium-pressure Hg lamps. This paper, co authored by Almac’s Megan Smyth and Tom Moody, discusses the development of a modern approach using a high power LED set-up emitting at the boundary of UV-A and visible light in conjunction with a continuous-flow reactor.

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