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Subject Matter Excellence: Tom Moody

Prof. Tom Moody graduated from The Queen’s University of Belfast with a 1st Class BSc(Hons) in chemistry in June 1998 before returning to gain a Ph.D. in Physical Organic chemistry in December 2001. He has also completed a Masters Degree in Business graduating with distinction in July 2007 specialising in business strategy. His work has earned him numerous accolades and is co-author and author of >50 publications and patents.

Tom is currently VP Technology Development and Commercialisation for Almac and Arran Chemical Company and works in the area of Chemistry & Biocatalysis and its application towards the synthesis of chiral molecules, metabolites and labelled compounds. Tom is responsible for managing a multi-disciplinary team of both chemists and biologists to obtain commercially useful biocatalysts for their intended applications.

Biocatalytic processes have been developed from mg to tonne manufacture, including development of fermentation processes, to yield the desired biocatalyst. He has been a scientific leader and problem solver in >50 commercial projects in the past 3 years and acts as a consultant in the area of biocatalyst development for pharmaceutical and biotech companies. He is also an honorary Professor at Queen’s University of Belfast in the area of biocatalysis.

Read Tom’s Latest article “Biocatalysis: Genes to GMP”

Patents

  1. Depre, Dominique Paul Michel; Ormerod, Dominic John; Horvath, Andras; Moody, Thomas Shaw; Brossat, Maude; Riant, Olivier; Vriamont, Nicolas; Lemaire, Sebastien Francois Emmanuel; Hermant, Sebastien Nicolas J.; PCT Int. Appl. (2016), WO 2016157058 A1 20161006. “Processes and intermediates for preparing Simeprevir, a macrocyclic protease inhibitor of HCV Process for the preparation of substituted quinazoline compound”.
  2. Luzung, Michael; Humphrey, Guy; Xiang, Bangping; Belyk, Kevin M.; Dalby, Stephen Mark; Schwab, Wilfried; Klenke, Burkhard; Moody, Tom; Brown, Gareth; PCT Int. Appl. (2015), WO 2015088931 A1 20150618, “Process for making substituted quinazoline compounds”.
  3. Liang, X., Högberg, T., Grue-Sørennsen, G., Moody, T.S. and Rowan, A. S., WO 2013/110753. 2013. “Process for the preparation of Ingenol-3-Angelate”
  4. Bornemeier, D. A.; Cai, C.; Fors, K. S.; Hagan, T. J.; Holsworth D. D., Jalaie, M.; Leonard, D. M.; Moody, T. S.; Take, Y.; PCT Int. Appl. WO20080502008. 2008. “Oxadiazole compounds as calcium channel antagonists”

Publications

  1. Declan P. Gavin, Aoife Foley, Thomas S. Moody, U. B. Rao Khandavilli, Simon E. Lawrence, Pat O’Neill, Anita R. Maguire, Tetrahedron: Asymmetry (2017), 28(4), 577-585, “Hydrolase-mediated resolution of the hemiacetal in 2-chromanols: the impact of remote substitution”.
  2. Carvalho, Alexandra; Dourado , Daniel ;  Quinn , Derek ; Moody, Thomas; Huang, Meilan; Journal:  ACS Catalysis, in press, “Catalytic mechanism of Baeyer-Villiger monooxygenases for linear substrates: implications on rational engineering BVMOs to expand the substrate specificity”
  3. Baud, Damien; Jeffries, Jack W. E.; Moody, Thomas S.; Ward, John M.; Hailes, Helen C.; Green Chem., 2017, 19, 1134–1143. “A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines”.
  4. Jeffries, Jack W. E.; Dawson, Natalie; Orengo, Christine; Moody, Thomas S.; Quinn, Derek J.; Hailes, Helen C.; Ward, John M.; ChemistrySelect (2016), 1(10), 2217-2220.  “Metagenome Mining: A Sequence Directed Strategy for the Retrieval of Enzymes for Biocatalysis”
  5. Dourado, Daniel ; Pohle, Stefan; Carvalho, Alexandra; Dheeman , Dharmendra; Caswell , Jill ; Skvortsov, Timofey ; Miskelly, Iain; Brown, Rodney; Quinn, Derek; Allen, Christopher; Kulakov , Leonid ; Huang, Meilan; Moody, Thomas, ACS Catalysis (2016), 6(11), 7749-7759.. “Rational design of a (S)-selective-Transaminase for asymmetric synthesis of (1S)-1-(1,1′-biphenyl 2-yl)ethanamine”
  1. Kelly, Paul P.; Lipscomb, David; Quinn, Derek J.; Lemon, Ken; Caswell, Jill; Spratt, Jenny; Kosjek, Birgit; Truppo, Matthew; Moody, Thomas S., Advanced Synthesis & Catalysis (2016), 358(5), 731-736, “Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols”.
  2. Wells, Andrew S.; Wong, John W.; Michels, Peter C.; Entwistle, David A.; Fandrick, Keith; Finch, Gregory L.; Goswami, Animesh; Lee, Heewon; Mix, Stefan; Moody, Thomas S., Organic Process Research & Development (2016), 20(3), 594-601, “Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form”
  3. Moody, T. S.; Mix, S.; Brown, G.; Beecher, D., Science of Synthesis, Biocatalysis in Organic Synthesis (2015), 2, 421-458, “Ketone and aldehyde reduction”.
  4. Baud, D.; Ladkau, N.; Moody, T. S.; Ward, J. M.; Hailes, H. C, Chemical Communications (Cambridge, United Kingdom) (2015), 51(97), 17225-17228, “A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase”.
  5. Jue Ling, Gaowa Naren, Jessica Kelly, Thomas S. Moody, and A. Prasanna de Silva, J. Am. Chem. Soc., 2015, 137 (11), pp 3763–3766, Publication Date (Web): March 9, 2015 (Communication), DOI: 10.1021/jacs.5b00665, “Building pH Sensors into Paper-Based Small-Molecular Logic Systems for Very Simple Detection of Edges of Objects”.
  6. Sean L Kitson, Tom Moody, William Watters, Modern Developments In Isotopic Labelling. http://www.outsourcedpharma.com/doc/modern-developments-in-isotopic-labelling-0001 [Access 03 September 2014].
  7. Kitson, S.L; Moody, T.S; Speed, D; Watters, W; Making Hot ADCs, Published online March 7, 2014, ADC Review / Journal of Antibody-drug Conjugates DOI: 10.14229/jadc.2014.3.3.001.
  8. Julia A. Griffen, Sarah J. Kenwright, Sarah Abou-Shehada, Scott Wharry, Thomas S. Moody and Simon E. Lewis, Org. Chem. Front., 2014, 1, 79, “Benzoate dioxygenase from Ralstonia eutropha B9 – unusual regiochemistry of dihydroxylation permits rapid access to novel chirons”.
  9. Rebecca E. Deasy, Thomas S. Moody, Anita R. Maguire, Tetrahderon: Asymmetry, 2013, 24(23), 1480-1487 “Influence of the position of the substituent on the efficiency of lipase-mediated resolutions of 3-aryl alkanoic acids”.
  10. Austin McMordie and Tom Moody, Manufacturing Chemist Pharma, October 2013, 51-53, “Natural enzymes – key to the 21st century process design”.
  11. Vladimir Zlateski, Roland Fuhrer, Fabian M. Koehler, Scott Wharry, Martin Zeltner, Wendelin J. Stark, Thomas S. Moody, and Robert N. Grass, Bioconjugate Chem., (2014), 25 (4), pp 677–684, “Efficient magnetic recycling of covalently attached enzymes on carbon-coated metallic nanomagnets”.
  12. Andrew S. Rowan, Thomas S. Moody, Roger M. Howard, Toby J. Underwood, Iain R. Miskelly, Yanan He and Bo Wang, Tetrahedron: Asymmetry, (2013), 24 (21-22), 1369-1381, “Preparatively accessing medicinal chemistry chiral alcohols using carbonyl reductase technology”.
  13. Sean L. Kitson, Vincenzo Cuccurullo, Thomas S. Moody and Luigi Mansi, Curr. Radiopharmaceuticals, (2013), 6(2), 57-71, “Radionuclide Antibody-conjugates, a Targeted Therapy Towards Cancer”.
  14. Sean L. Kitson, Thomas S. Moody, Derek J. Quinn, and Alastair Hay, Carbon-14 Bioconjugation: Peptides and Antibody-Drug Conjugates, May 8th issue of The Pharmaceutical Sciences, Manufacturing & Marketplace Report, in press 2013.
  15. Moody, Tom; Mix, Stefan, Speciality Chemicals Magazine (2013), 33(9), 24, 26, “Biotransformations in Chemical Synthesis”.
  16. Sean L. Kitson, Thomas S. Moody, Derek J. Quinn, David Rozzell and David Speed, Antibody-Drug Conjugates (ADCs) – Biotherapeutic Bullets, Monographic supplement series of Chimica Oggi / chemistry Today: CROs/CMOS- 31(4), 30-36, July August 2013.
  17. Sean L Kitson, Thomas S Moody, David Rozzell, Jill Caswell Drug Discovery and Development Article, in press, 2013, “Antibody-Drug Conjugates (ADCs): Carbon-14 Labelling Requirements”.
  18. Alastair Hay, Sean L Kitson, Thomas S Moody and Derek Quinn,  Pharmaceutical Sciences, Manufacturing & Marketplace Report, in press, 2013, “Making Carbon-14 Labelled Peptides Available to BioPharma”.
  19. Jill M. Caswell, Maeve O’Neill, Thomas S. Moody and Steve J.C. Taylor, Curr. Opin. Chem. Biol, Vol 17, Issue 2, 271-275, 2013, “Engineering and application of P450 monooxygenases in pharmaceutical and metabolite synthesis”.
  20. Moody, Tom; Brown, Gareth, From Pharmaceutical Technology (2012), (Suppl.), s12, s14-s15, “Making APIs Greener”.
  21. David Mangan, Iain Miskelly, and Thomas S. Moody; Adv. Syn. Catalysis, 2012, 354(11-12), 2185-2190, “A three enzyme system involving an ene-reductase for generating valuable chiral building blocks”.
  22. S. Zheng, T.S. Moody, P.L.M. Lynch, H.Q.N. Gunaratne, T.E. Rice and A.P. de Silva, Photochem. Photobiol. Sci.  2012, 11, DOI:10.1039/c2pp25069a. “Structural effects on the pH-dependent fluorescence of naphthalenic derivatives and consequences for sensing/switching”.
  23. Susan J. Calvin, David Mangan, Thomas S. Moody and Paul J. Stevenson Org. Process Res. Dev. 2012, 16 (1), pp 82–86, “Overcoming equilibrium issues with carbonyl reductase enzymes”.
  24. Sutton, Peter W.; Adams, Joseph P.; Archer, Ian; Auriol, Daniel; Avi, Manuela; Branneby, Cecilia; Collis, Andrew J.; Dumas, Bruno; Eckrich, Thomas; Fotheringham, Ian, D. Mangan and Thomas S. Moody, “Biocatalysis in the fine chemical and pharmaceutical industries”; Practical Methods for Biocatalysis and Biotransformations 2, edited by John Whitall and Peter Sutton. Published by John Wiley and Sons Ltd., 2012, 1-59.
  25. D. Mangan and Thomas S. Moody, “Bioreduction using immobilized carbonyl reductase technology”; Practical Methods for Biocatalysis and Biotransformations 2, edited by John Whitall and Peter Sutton. Published by John Wiley and Sons Ltd., 2012, 116-118.
  26. D. Mangan and Thomas S. Moody, “Alpha-keto biooxidation using Cunninghamella echinulata (DSM 63356)”; Practical Methods for Biocatalysis and Biotransformations 2, edited by John Whitall and Peter Sutton. Published by John Wiley and Sons Ltd., 2012, 147-150.
  27. Milner, Sinead E.; Moody, Thomas S.; Maguire, Anita R.; European Journal of Organic Chemistry, 2012, 2012(16), 3059-3067, “Biocatalytic Approaches to the Henry (Nitroaldol) Reaction”.
  28. O’Neill, Maeve; Beecher, Denis; Mangan, David; Rowan, Andrew S.; Monte, Agnieszka; Sroka, Stefan; Modregger, Jan; Hundle, Bhupinder; Moody, Thomas S.,  Tetrahedron: Asymmetry, 2012, 23(8), 583-58, “A novel lipase enzyme panel exhibiting superior activity and selectivity over lipase B from Candida antarctica for the kinetic resolution of secondary alcohols”.
  29. Deasy, Rebecca E.; Brossat, Maude; Moody, Thomas S., Maguire, Anita R., Tetrahedron: Asymmetry, 2011, 22(1), 47-61, “Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids”.
  30. Allen, P. H.; Bloom, A. J.; Bragg, R.; Brown, R. T.; Burgos, A.; Bushby, N.; Clarke, M. L.; Dudin, L. F.; Ellames, G. J.; Gee, A. D.; Gouverneur, V.; Harding, J. R.; Harrowven, D. C.; Herbert, J. M.; Hickey, M. J.; Husbands, S.; Jennings, L. E.; Jones, M.; Kealey, S.; Killick, D.; Kingston, L. P.; Kitson, S. L.; Kohler, A.; Kostiuk, S. L.; Le Strat, F.; Light, M. E.; Lockley, W. J. S.; Long, N. J.; McNeill, A. H.; Miller, P. W.; Moody, T. S.; Murrell, V. L.; Nanson, L.; Pedersen, M. H. F.; Pinney, K. G.; Plisson, C.; Schou, S.; Sharma, R. S.; Shaw, I.; Sherhod, R.; Smith, T.; Sriram, M.; Tate, J.; Tredwell, M.; Twiddy, S.; Watters, W.; White, A. J. P.; Wilkinson, D. J.; Woodcock, T. Division of Chemistry, Faculty of Health & Medical Sciences, University of Surrey, Surrey,UK, Journal of Labelled Compounds and Radiopharmaceuticals, 2011, 54(7), 387-398, ”19th international isotope society (UK group) symposium: synthesis & applications of labelled compounds 2010”.
  31. Mangan, David; Moody, Tom.; Speciality Chemicals Magazine, 2011, 31(11), 20, 22, “Spoilt for choice”.
  32. Maguire, Nuala M.; Ford, Alan;Clarke, Sarah L.; Eccles, Kevin S.; Lawrence, Simon E.; Brossat, Maude; Moody, Thomas S.; Maguire, Anita R; Tetrahedron: Asymmetry, 2011, 22(24), 2144-2150, “A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates”.
  33. Moody, Tom and Stefan Mix; Pharma magazine, September issue, 2011, “Choosing biocatalysis to accelerate chemical development, minimise cost for fine chemical and API manufacture and metabolite synthesis”.
  34. Gareth Brown, David Mangan, Iain Miskelly, and Thomas S. Moody, Org. Process Res. Dev., 2011, 15 (5), pp 1036–1039, “A Facile Stereoselective Biocatalytic Route to the Precursor of Woody Acetate”.
  35. Moody, Tom; Geffroy, D,. Sp2 magazine, January, 27-29, 2011, “Biocatalysis is the key to successful chiral synthesis”.
  36. Sinead E. Milner, Maude Brossat, Thomas S. Moody, Curtis J. Elcoate, Simon E. Lawrence, Anita R. Maguire; Tetrahedron Asymm., 21, 1011-1016, 2010, “Efficient kinetic bioresolution of 2-nitrocyclohexanol”.
  37. Moody, T. S.; Pharma Chem, April/May edition, 36-38, 2010. “Cleaner processes using biocatalyst purification tools at Almac Sciences”.
  38. A. Prasanna de Silva,Thomas S. Moody, Glenn D. Wright, Analyst, 2009, 134, 2385-2393. Fluorescent PET (Photoinduced Electron Transfer) sensors as potent analytical tools.
  39. Thomas S. Moody, Maude Brossat, Stephen J. C. Taylor and Jonathan W. Wiffen, Tetrahedron Asymm., 20, 18, 2112-2116 2009. “Efficient process for the solvent-free bioresolution of tertiary amino alcohol protic ionic liquids”.
  40. Moody, T. S., Taylor, S. J. C.; sp2 magazine, December, 30-32, 2009. “Biocatalysts fuel the chiral line at Almac Sciences”.
  41. Emmanuelle Alanvert, Claire Doherty, Thomas S. Moody, Nicholena Nesbit, Andrew S. Rowan, Stephen J.C. Taylor, Fatima Vaughan, Tony Vaughan, Jonathan Wiffen and Ian Wilson, Tetrahedron Asymm., 20, 2009, 2462-2466. “Highly stereoselective biocatalytic reduction of alpha-halo ketones”.
  42. Brossat, M.; Moody, T. S.; de Nanteuil, F.; Taylor, S. J. C.; Vaughan, F. Org. Process. Res. Dev. 13 (4), 706–709, 2009, Development of an acid washable tag for the separation of enantiomers from bioresolutions.
  43. Moody, T. S., Taylor, S. J. C.; Fuelling the Chiral Line with Biocatalysis Power, Speciality Chemicals, Jan 2009, 51-53.
  44. Prasanna de Silva, A.; McClean, Gareth D.; Moody, Thomas S.; Weir, Sheenagh M.  Luminescent sensors and switches.  Handbook of Photochemistry and Photobiology, 2003, 3, 217.
  45. A.P. de Silva, D.B. Fox, T.S. Moody and S.M. Weir Handbook of Photochemistry and Photobiology American Scientific Publishers, New York, 2001, commissioned for September 2001 (Editors: M.S.A. Abdel-Mottaleb and H.S. Nalwa) “Luminescent Sensors and Switches”.
  46. A.P. de Silva, N.D. McClenaghan, G. McClean, T.S. Moody and S.M. Weir Nachr. Chem. Tech. Lab. 2001, 49, 602 “Logische Schaltungen mit Leuchtenden Molekulen”.
  47. A.P. de Silva, D.B. Fox, T.S. Moody and S.M. Weir Pure Appl. Chem. 2001, 73, 503 (Editor: H.J. Kuhn) “Luminescent Sensors and Photonic Switches”
  48. A.P. de Silva, D.B. Fox, T.S. Moody and S.M. Weir, Molecular and Supramolecular Photochemistry Dekker, New York, 2001, 7, 93 (Editors: V. Ramamurthy and K.S. Schanze), “Luminescent PET (Photoinduced Electron Transfer) Signalling Devices”.
  49. A.P. de Silva, D.B. Fox, T.S. Moody and S.M. Weir, Trends Biotechnol. 2001, 19, 27, “Development of Molecular Fluorescent Switches”.
  50. A.P. de Silva, D.B. Fox and T.S. Moody, Stimulating Concepts in Chemistry Wiley-VCH, Weinheim, 2000, 307 (Editors: M. Shibasaki, J.F. Stoddart and F. Vogtle), “Luminescence Logic and Sensing”.
  51. A.P. de Silva, D.B. Fox, A.J.M. Huxley, N.D. McClenaghan and T.S. Moody Coord. Chem. Rev. 2000, 205, 41 (Editor: L. Fabbrizzi), “Combining Luminescence, Co-ordination and Electron Transfer for Signalling Purposes”.

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