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- Peptide & Protein Technology
- rapidd™
- Analytical
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- Isotope Chemistry
- Biocatalysis / selectAZyme™
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- Animal Free Chemokines
Keyword
PEGylation of antibody fragments: anti-EGFR single domain antibody
Antibody fragments
- Nanobodies are the smallest available intact antigen binding domains
- 120-130 amino acids
- Contain 1 or 2 conserved disulphide bridges
- Rapid clearance from blood (half life ~10 mins)
Attractive target for PEGylation
- Increase in vivo half life
- Reduced immunogenicity and proteolysis
- Better targeting to tumour tissues - (Enhanced permeability and retention effect)
Labelling is high yielding and cost-effective
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PK properties are improved by Almac PEGylation technology
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