PEGylation of antibody fragments: anti-EGFR single domain antibody

PEGylation of antibody fragments: anti-EGFR single domain antibody

Antibody fragments

  • Nanobodies are the smallest available intact antigen binding domains
  • 120-130 amino acids
  • Contain 1 or 2 conserved disulphide bridges
  • Rapid clearance from blood (half life ~10 mins)

Attractive target for PEGylation

  • Increase in vivo half life
  • Reduced immunogenicity and proteolysis
  • Better targeting to tumour tissues - (Enhanced permeability and retention effect) 

Labelling is high yielding and cost-effective

 

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PK properties are improved by Almac PEGylation technology

 

 

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