A Concise Enantioselective Formal Synthesis of the Second-Generation Oral Contraceptive Levonorgestrel

This article presents a concise and scalable approach to synthesising a key precursor of the second-generation oral contraceptive levonorgestrel. By combining biocatalysis with established chemical steps, the authors introduce an efficient route that delivers high stereoselectivity, improved process efficiency, and strong potential for cost-effective large-scale production.

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