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Development and Scale-Up of an Antibody Drug Conjugate Tubulysin Payload

Read how significant development and scale-up work was completed on the synthesis of an antibody drug conjugate payload based on the tubulysin natural products.
This work included the development of new routes, as well as extensive optimisation of the solid phase peptide synthesis used to assemble the molecule. Find out how the initial route was improved to a new, more robust route, affording a 240-fold increase in overall yield and allowing delivery of over 86 g of the required molecule.

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Almac API, Chemical Development, Analytical & Solid State Services

Almac Sciences provides integrated services from development to commercial scale of advanced intermediates and Active Pharmaceutical Ingredients (API).

We provide a range of services for small molecules (including highly potent) and peptides. We have a proven track record of saving time and cost through the integration of our services and application of innovative biocatalysis and technology solutions.

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Our vast pool of scientific knowledge can help to overcome the analytical challenges that typically arise during drug development.

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