Diastereoselective Total Synthesis of the Key Synthetic Precursor of the Third-Generation Oral Contraceptive Etonogestrel

This article outlines a streamlined and scalable approach to synthesising a key precursor of the oral contraceptive etonogestrel. By refining the process and reducing it to a shorter, more efficient route, the work demonstrates improvements in yield, selectivity, and overall practicality for large-scale production.

Explore the full article to uncover the detailed chemistry, optimisation strategy, and scale-up insights behind this advancement.