Safeguarding Potency: Innovative Containment Strategies for HPAPI Manufacturing

In this article, James Millar, Operations Support Manager (Manufacturing Support) at Almac Pharma Services, explores how the rise of high potency APIs (HPAPIs) is reshaping pharmaceutical manufacturing. As these compounds become more central to oncology, rare disease, and personalized therapies, the need for advanced containment strategies is growing rapidly.

The article outlines how CDMOs are embedding containment into every layer of their operations—from facility design and equipment investment to agile processes and safety culture. It also highlights the broader forces driving this shift, including regulatory pressure, therapeutic complexity, and sustainability goals.

To explore how containment is becoming a strategic differentiator in high-potency manufacturing, download the full article: