Megan Smyth

Current Role:

As Team Leader, Megan leads multiple custom synthesis projects developing processes from gram to tonne manufacture and is responsible for technology transfer and process scale-up with additional experience in bioprocessing. Megan has been responsible for the implementation of continuous flow at Almac Sciences, additionally leading multiple academic collaborations and has eight peer-reviewed flow publications in the last two years.

Previous Experience:

Megan graduated from The Queen’s University of Belfast with a 1st Class MSci (Hons) in Chemistry in 2012 before returning to gain a Ph.D. in 2016. In 2022, Megan completed an MBA (with distinction) at the University of Aberdeen.

Joined Almac:

2016

Publications:

1. Continuous flow photooxidation of alkyl benzenes using ultra-fine bubbles for mass transfer enhancement, Gary Morrison, Scott Wharry, Thomas S. Moody, Nobuyuki Mase, Masayuki Hattori, Haresh Manyar and Megan Smyth, Tetrahedron Letters, 2022, 90, 153613 https://doi.org/10.1016/j.tetlet.2021.153613
2. Evaluating the Green Credentials of Flow Chemistry towards Industrial Applications, Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry, Synthesis, 2021, DOI: 10.1055/a-1541-1761.
3. Interrupted Curtius Rearrangements of Quaternary Proline Derivatives: A Flow Route to Acyclic Ketones and Unsaturated Pyrrolidines, Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry, J. Org. Chem. 2021, 86, 20, 14199–14206, doi: 10.1021/acs.joc.1c01133.
4. Coupling Biocatalysis with High-Energy Flow Reactions for the Synthesis of Carbamates and β-Amino Acid Derivatives, Marcus Baumann, Alexander Leslie, Thomas S. Moody, Megan Smyth and Scott Wharry, Beilstein J. Org. Chem. 2021, 17, 379-384.
5. Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme Mediated Impurity Tagging, Marcus Baumann, Alexander Leslie, Thomas S. Moody, Megan Smyth and Scott Wharry, Org. Process Res. Dev., 2020, 25, 3, 452-456, doi: 10.1021/acs.oprd.0c00420.
6. Overcoming the Hurdles and Challenges Associated with Development of Continuous Industrial Processes, Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry, Eur. J. Org. Chem., 2020, 48, 7398-7406, doi: 10.1002/ejoc.202001278.
7. Cover Feature: Overcoming the Hurdles and Challenges Associated with Development of Continuous Industrial Processes, Industrial Processes, Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry, Eur. J. Org. Chem., 2020, 48, 7397 doi: 10.1002/ejoc.202001376.
8. FAST hydrogenations as a continuous platform for green aromatic nitroreductions, MD Taifur Rahman, Haresh Manyar, Thomas S. Moody, Megan Smyth and Scott Wharry, Synlett, 2020, 31, 581-586, doi: 10.1055/s-0037-1610751.
9. A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry, Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry, Org. Process Res. Dev., 2020, 24, 10, 1802-1813, doi: 10.1021/acs.oprd.9b00524.