Pre-Clinical Package for Small Molecules
Identifying Candidates and Highlighting Potential Pitfalls
Our pre-clinical package for small molecules offers an intelligent, rapid, and economical approach for lead identification. Designed to identify candidates with drug product-like characteristics, it will also highlight the potential pitfalls associated with the molecules.
Experimental efforts concentrate on establishing the physical / chemical, solubility, stability and polymorphic characteristics of each candidate. The information generated can then be used to make a rational decision for lead identification.
|Crystallinity (XRPD, PLM)|
Melting point (DSC)
Particle size and shape (microscopy)
Log P, pKa and lipophilicity profile
|A lean polymorph screen on each candidate to establish the polymorphic landscape and determine the tendency to form hydrates or solvates||Pharmaceutical solvents|
|Development of stability indicating LC-MS methodSolid state stability|
(heat, humidity, light)Solution stability
(pH, oxidation, heat, light)
Timelines and Costs
It is anticipated that the pre-clinical package will be completed in 4 weeks. Typically, we customize studies to our clients’ needs and budget. Quotations are available on request.