State of the Art Laboratories

Our global state-of-the art laboratories based in Craigavon, UK and Durham NC, USA, alongside our partnership lab in Shanghai, China are ready to operate both research-use-only and clinical diagnostic assays.

We have fully automated processing in place and a full laboratory information management system, which tracks samples from receipt to the completion of your study.

Partnering with Almac Diagnostics, you will have access to extensive bioinformatics, project management and quality & regulatory supporting expertise. We also offer a range of supporting lab services, from sample sourcing and tissue processing to immunohistochemistry and pathology review.

You can make use of any of these services in a fee-for-service manner for routine genomic research.

We already offer clients a wide range of platforms but will adopt additional technologies as required.

RNA Analysis

Almac has over ten years’ RNA profiling experience and has processed tens of thousands of samples for gene expression analysis using a range of tissue types including peripheral blood, bone marrow, sputum, CSF and solid tissue.

Our specific area of expertise is working with degraded RNA from FFPE samples. This difficult sample type is used routinely in our labs for both biomarker discovery and routine clinical testing. Our research and diagnostic systems handle a range of complexity and processing rates, from low to extremely high.

Through our expertise we’ve developed our own range of biomarker discovery tools; the Xcel Array and Cancer DSA Arrays, which are microarray-based tools optimized for biomarker research in FFPE tissue. We have developed specialist skills in working with FFPE in qPCR & NGS platforms. We have used these tools extensively for both biomarker discovery and development and in the delivery of clinical assays in routine testing.

DNA Analysis

From Traditional Sanger Sequencing to Next Generation Sequencing

We offer qPCR services for DNA analysis and array-based systems such as the Affymetrix DMETTM, Oncoscan®, Cytoscan® and routine SNP arrays. All of our DNA analysis services can be utilised in both a research and a diagnostics manner. The platforms we use for DNA analysis are suitable for diagnostic delivery and we have a number of CLIA validated assays available, such as the Cobas® KRAS, BRAF and EGFR.

We have also developed our own CLIA validated next generation sequencing assay for the P53 oncogene. This test has been developed in collaboration with Illumina® and is delivered on the Illumina MiSeq platform from our CLIA/CAP lab.

Our Range of Platforms

DNA Analysis

  • Illumina MiSeq®
  • Illumina NextSeq
    -Illumina TST170
  • Thermo Fisher Ion Torrent PGM Dx
  • Sanger Sequencing
    -MSI
  • Nanostring nCounter
  • Fluidigm Biomark HD
  • Roche LightCycler
  • Affymetrix
    -SNP 6.0, DMET, OncoScan

RNA Analysis

  • Illumina MiSeq®
  • Illumina NextSeq
  • Thermo Fisher Ion Torrent PGM Dx
  • Thermo Fisher/LifeTechnologies Quantstudio Dx
  • Roche LightCycler
  • Fluidigm BioMark HD
  • Nanostring nCounter
  • Affymetrix
    -RUO & DX V2 Genechip Systems
    -Xcel Array
    -Cancer DSA Arrays (Breast, Colorectal, Ovarian, Lung, Prostate)

Supporting Lab Services 

  • Pathology
  • Sample sourcing
  • IHC, ISH, FISH, ELISA
  • Tissue pre-processing
  • Digital image scanning

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