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DNA Damage Response Deficiency Assay predicts response to treatment in ovarian cancer

Ovarian cancer is the leading cause of death from gynaecological malignancies. The standard first line therapy is a combination of carboplatin and paclitaxel and has a response rate of 70%-80%, although the majority relapse. Almac have previously developed a 44 transcript DNA damage response deficiency (DDRD) assay which indicates loss of the FA/BRCA pathway and predicts response to DNA damaging agents. In this study we have investigated the utility of the DDRD assay predicting response to platinum based therapy in ovarian cancer.

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