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Biocatalysis: Greener, sustainable processes using efficient biocatalyst purification tools at Almac Sciences

The need for green, economic, robust, scaleable and reliable processes for the synthesis of chiral APIs and intermediates prompted Almac to build and fully integrate a biocatalysis group into its service portfolio. The dedicated group based at the Belfast site has expertise in gene identification, expression, fermentation and biocatalyst production. This is followed by the efficient use of biocatalysts to produce clean and sustainable routes to complex chiral APIs and intermediates.

The biocatalysis group is closely linked to process and GMP pilot plant chemistry groups where biocatalyst discovery and development is integrated with screening, route definition and subsequent scale-up.

The group applies expertise to complex chemical processes, rapidly implementing biocatalytic steps to significantly improve the yield and reduce waste for multi-stage syntheses.

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Almac API, Chemical Development, Analytical & Solid State Services

Almac Sciences provides integrated services from development to commercial scale of advanced intermediates and Active Pharmaceutical Ingredients (API).

We provide a range of services for small molecules (including highly potent) and peptides. We have a proven track record of saving time and cost through the integration of our services and application of innovative biocatalysis and technology solutions.

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We offer a full suite of analytical testing for a range of different product types including small molecules, peptides, biologics, conjugates, potent and controlled substances.

Our vast pool of scientific knowledge can help to overcome the analytical challenges that typically arise during drug development.

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