Home / Knowledge Centre /
Technical Publication

Building pH Sensors into Paper-Based Small-Molecular Logic Systems for Very Simple Detection of Edges of Objects

Genetically engineered bacteria and reactive DNA networks detect edges of objects, as done in our retinas and as also found within computer vision.
We now demonstrate that simple molecular logic systems (a combination of a pH sensor, a photo acid generator, and  a pH buffer spread on paper) without any organisation can achieve this relatively complex computational goal with good fidelity. This causes a jump in the complexity achievable by molecular logic-based computation and extends its applicability.
The molecular species involved in light dose-driven “off−on−off” fluorescence is diverted in the “on” state by proton diffusion from irradiated to unirradiated regions where it escapes a strong quencher, thus visualising the edge of a mask.
Download to read the full technical paper.

View Resource
Almac Logo

Almac API, Chemical Development, Analytical & Solid State Services

Almac Sciences provides integrated services from development to commercial scale of advanced intermediates and Active Pharmaceutical Ingredients (API).

We provide a range of services for small molecules (including highly potent) and peptides. We have a proven track record of saving time and cost through the integration of our services and application of innovative biocatalysis and technology solutions.

Learn More

We offer a full suite of analytical testing for a range of different product types including small molecules, peptides, biologics, conjugates, potent and controlled substances.

Our vast pool of scientific knowledge can help to overcome the analytical challenges that typically arise during drug development.

Learn More

Download here instantly

This website uses cookies. By continuing to browse the site, you are agreeing to our use of cookies