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Identification and Structural Elucidation by Amino Acid Sequencing of Peptide Impurities by 2D-LC MS/MS

Peptide impurity profiles require increasingly complex separation methods in order to detect and adequately quantitate peptide impurities. Mobile phase conditions optimal for these separations in most cases consist of non-volatile salt based buffer systems that are not inherently LC/MS compatible. 2D-LC has been demonstrated to overcome this issue by extracting the impurity peaks of interest and transferring them to a mass spectrometry compatible solvent system for further analysis.
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