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Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology

Background: Approximately 4–25% of patients with early prostate cancer develop disease recurrence following radical prostatectomy.

Objective: To identify a molecular subgroup of prostate cancers with metastatic potential at presentation resulting in a high risk of recurrence following radical prostatectomy.

Design, setting, and participants: Unsupervised hierarchical clustering was performed using gene expression data from 70 primary resections, 31 metastatic lymph nodes, and 25 normal prostate samples. Independent assay validation was performed using 322 radical prostatectomy samples from four sites with a mean follow-up of 50.3 months.

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