Psilocybin: Characterization of the Metastable Zone Width (MSZW), Control of Anhydrous Polymorphs, and Particle Size Distribution (PSD)

The Food and Drug Administration for clinical trials involving major depressive disorder and treatment-resistant depression granted psilocybin a “breakthrough therapy” status. The direct phosphorylation of psilocin to psilocybin that uses a fast crystallization associated with a kinetically controlled process resulted in a smaller particle size distribution.

The quest for an ideal crystallization process in the past has been enigmatic but has become a very commonly used separation process in many different industries, including materials and pharmaceutical industries. This article aims to investigate the applicability of a crystal engineering technique that improves the physicochemical properties of psilocybin API.

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