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Radiolabelling: Synthesis of 14C-Labelled Peptide

This case study highlights the manufacture and supply of 14C-labelled antibody drug conjugate for a drug development programme.
Almac was approached to prepare 2mg of 14C-labelled biotinylated peptide. The 14C-label was required on the N-terminus amino acid isoleucine with a specific activity of >300mCi/mmol. The peptide chain contained 84 amino acids and was considered a complex synthetic target.

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Almac API, Chemical Development, Analytical & Solid State Services

Almac Sciences provides integrated services from development to commercial scale of advanced intermediates and Active Pharmaceutical Ingredients (API).

We provide a range of services for small molecules (including highly potent) and peptides. We have a proven track record of saving time and cost through the integration of our services and application of innovative biocatalysis and technology solutions.

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We offer a full suite of analytical testing for a range of different product types including small molecules, peptides, biologics, conjugates, potent and controlled substances.

Our vast pool of scientific knowledge can help to overcome the analytical challenges that typically arise during drug development.

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