Rational engineering of a carboxylesterase for the synthesis of polyesters for biomedical applications

Enzymatic synthesis of poluymeric biobased materials is a powerful approach to make these processes greener, more economical, and safer for scale-up. Herein, we have reengineered a hyperthermophilic carboxylesterase to improve product yield in the synthesis of poly(E-caprolactone) and triblock poly(E-caprolactone)-co-poly(ethylene glycol), two important biomaterials.

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