Accelerating Outcomes with a Pancreatic Cancer Adaptive Platform
When the Pancreatic Cancer Action Network© were launching an important master protocol trial designed to accelerate outcomes in a cancer with a less than 10% survival rate, they were presented with a challenge:
How do you set up an IRT system for a perpetual design to account for seamless introduction of new investigational treatments?
When your goal is to identify effective and ineffective treatments more quickly than traditional trials through a Complex Innovative Design, the right IRT system is crucial.
In this case study, we discuss:
- How a Complex Innovative Design is used to evaluate multiple treatments in multiple patient populations and why leveraging a flexible IRT is key
- Why early and frequent collaboration amongst key players drives successful implementation of the IRT for Complex Innovative Designs.
- How IRT systems can be built to accommodate future unknowns.
- Leveraging a Bayesian Response-Adaptive Randomization (BRAR) algorithm to “learn as you go” and how the IRT dynamically responds to changing probabilities.
Almac Clinical Technologies
Almac Clinical Technologies is here to help the biopharmaceutical industry bring new therapies to those in need by empowering clinical trial sponsors to proactively manage sites, patients, and clinical trial supplies through our industry-leading Interactive Response Technology (IRT) and expert consultancy.
Almac Clinical Technologies is uniquely positioned to unlock new efficiencies in the clinical supply chain and to help achieve greater predictability in your projects and programs.
Our professionals are dedicated to delivering high-quality Interactive Response Technology (IRT) solutions, dependable professional services, and reliable customer service. Our expertise, energy, and commitment have earned us a reputation as a trusted ally in the drug development process.