Enzyme identification and engineering for novel industrial enzymes with Twist Biosciences
In the last 40 years, advances in protein engineering and evolution have prompted the application of biocatalysts in the synthesis of active pharmaceutical ingredients (API), as well as fine and bulk chemicals for the agrochemical, food, biofuel, and pharmaceutical industries. Computational chemistry methodologies in conjunction with smart variant library generation and high-throughput screening are fuelling the development of a new generation of rationally designed biocatalysts with enhanced selectivity and specificity at a fraction of the time and cost of what was achievable a mere decade ago.
Watch our webinar with Dr. Derek Quinn, Senior Biology Team Leader for Biocatalysis in conjunction with Twist Biosciences, to:
- Learn how novel biocatalysts can be identified using bioinformatics, in silico design, gene synthesis, and rapid screening.
- Hear how the best candidate enzymes can then be further improved by engineering/evolution.
- Review several case studies showcasing this approach.
- See how Almac is leveraging Twist’s scalable DNA synthesis platform to power these projects with many hundreds of genes.
Almac API, Chemical Development, Analytical & Solid State Services
Almac Sciences provides integrated services from development to commercial scale of advanced intermediates and Active Pharmaceutical Ingredients (API).
We provide a range of services for small molecules (including highly potent) and peptides. We have a proven track record of saving time and cost through the integration of our services and application of innovative biocatalysis and technology solutions.
We offer a full suite of analytical testing for a range of different product types including small molecules, peptides, biologics, conjugates, potent and controlled substances.
Our vast pool of scientific knowledge can help to overcome the analytical challenges that typically arise during drug development.