£13m Investment Cancer Research Initiatives with QUB

September 4, 2013

Almac/Queen’s Announce Cancer Research Initiatives Representing £13 Million Investment

In a dual announcement Almac Discovery Ltd and Queen’s University Belfast (QUB) have revealed the launch of a formal working partnership between Almac and the Center for Cancer Research and Cell Biology (CCRCB) at Queen’s, and a significant milestone in the development of a ground breaking new cancer drug ALM201. Taken together, the two projects represent a total investment of £13 million, which includes some financial support from Invest Northern Ireland, part funded by the European Regional Development Fund.PEYE-FOSTER-ALMAC-0001-450x300Pictured at Queen’s Center for Cancer Research and Cell Biology (CCRCB) on the Belfast City Hospital campus are, left to right: Prof David Waugh, Director, Center for Cancer Research and Cell Biology, Alan Armstrong, CEO Almac and Enterprise Minister Arlene Foster.

ALM201 is a drug candidate derived from a natural protein originally discovered by a Queen’s School of Pharmacy research team led by Professor Tracy Robson, and developed by Almac Discovery Ltd in Craigavon in collaboration with Professor Robson. It is an anti-angiogenic drug which works by preventing the growth of new blood vessels thereby inhibiting tumor growth. However ALM201, unlike the majority of other anti-angiogenic therapies on the market, works by an entirely new mechanism and hence has the potential to treat a wider range of patients than currently possible including those resistant to existing therapies.

With preclinical studies successfully completed the drug has reached a significant milestone as Phase 1 clinical trials are scheduled to begin in early 2014. The three year trial will be led by Dr. Richard Wilson, Director of the Northern Ireland Clinical Trials Unit at Queen’s and managed by Almac Discovery and will be run from Belfast and two other UK based clinical trial Centers.

Today also marked the formal launch of the Almac/CCRCB joint Drug Discovery Partnership and the announcement of Professor Tim Harrison as the inaugural McClay Chair of Medicinal Chemistry who will head up the collaborative program.

Alan Armstrong, CEO of the Almac Group explains; “Almac and Queen’s have already demonstrated through the creation and development of ALM201 how valuable and productive such a world class partnership between academia and industry can be. By integrating academic and clinical researchers with experienced industrial scientists we have the means to accelerate cancer focused drug discovery towards the ultimate goal of improving patient care. A team of 17 Almac scientists will be seconded to Queen’s for three years and the combined unit will create a coordinated drug discovery and development pipeline. Resultant products will then continue their development journey with other appropriate partners towards patient-enriched trials and ultimately commercial production. This single-location integrated approach puts the initiative at a distinct advantage and reflects Northern Ireland’s aim to compete more effectively as a modern knowledge based economy.”

Professor James McElnay, Acting President and Vice-Chancellor of Queen’s, added: “Queen’s and Almac are recognized internationally as being leading innovators in the world of drug discovery and cancer research.  Today’s announcement, therefore, heralds an important new era for patients in Northern Ireland and beyond. Not only is our newest collaboration set to deliver significant future economic benefits for Northern Ireland, it will also result in an increase in the development of potential new therapeutic approaches for patients, and accelerate the process in which treatments move from the lab bench to bedside.”

Making the announcement, Enterprise Minister, Arlene Foster said, “Almac is a highly respected and successful drug development company focusing on innovative cancer treatments that have global potential. This significant investment in research and development will enhance collaboration between academia and industry.  This will ensure the investment is maximized, that research is effectively commercialized and that ultimately, enhanced treatment solutions are made available to cancer patients.”

 

Ends

 

Notes to Editors

  • Almac Discovery is an independent member of the Almac Group. The company is focused on the discovery and development of novel and innovative approaches to the treatment of cancer and associated conditions. Almac Discovery is located in Craigavon, Northern Ireland. For more information, please visit www.almacgroup.com/discovery/.
  • ALM201 is a fragment of a natural protein discovered in the School of Pharmacy at Queen’s by a research team led by Professor Tracy Robson. The compound was developed jointly by Almac Discovery in Craigavon and Professor Robson.
  • The ALM201 trial will involve up to 60 patients who are being treated for ovarian cancer.  It will be led by Dr Richard Wilson, Director of the Northern Ireland Clinical Trials Unit at Queen’s.  Rather than attacking tumors directly, ALM201 prevents the growth of new blood vessels in tumors, starving them of oxygen and nutrients and thereby preventing their growth.  It targets tumors by an entirely different pathway to other treatments currently approved.
  • The new Almac Discovery/CCRCB drug discovery joint program in Cancer Drug Discovery will see the discovery team work to identify parts of tumors which are susceptible to treatment by cancer drugs and to then develop the new drugs to target them.  The partnership will also enable new approaches to selecting those patients who will be most likely to respond to the new drugs, and to create the technologies needed to deliver the drugs directly to the tumor site in the patient.
  • Alan Armstrong joined Galen Research Laboratories in 1978 in the quality control department where he took over as Quality Assurance Manager in 1982. Alan held a number of senior management operational and technical positions until 1995 when he was appointed to the Board of Directors of Galen Holdings Plc as Chief Operating Officer. In 2002 he retired from Galen Holdings and was appointed CEO of Almac. Alan oversees the entire Group’s operations globally and leads the strategic direction of Almac.
  • Almac Sciences’ Managing Director, Dr Stephen Barr, joined QuChem Limited in 1994 as a synthetic chemist, having completed a two year Postdoctoral Fellowship at the Queen’s University of Belfast. Following the merger of QuChem Ltd and Syngal to form Almac Sciences, he was promoted to Vice President with full responsibility for all technical operations, becoming Managing Director in 2001. In 2007 Stephen was responsible for the development of a Drug Discovery business plan which involved securing funding through Invest Northern Ireland for this new and exciting venture.  He assumed full responsibility for the establishment, staffing and operation of this new division, Almac Discovery and was appointed President and MD.
  • Professor Tim Harrison joined Almac Sciences in 2006 as Vice President, Research and Development. He played a key role in setting up Almac Discovery where he currently holds the post of Vice President, Discovery Chemistry. In 2011 Tim played a leading role in the development of a joint collaborative program with Queen’s University Belfast, which focused on the identification of new oncology targets together with drug leads.
  • The Almac/CCRCB collaboration was born out of this program in 2013 and included the creation of the McClay Chair of Medicinal Chemistry. Tim is the inaugural holder of this chair and now splits his time between this academic role and his Almac position.
  • The Almac Group is an established contract development and manufacturing organization that provides an extensive range of integrated services to over 600 companies globally within the pharmaceutical and biotech sectors. The services range from R&D, biomarker discovery and development, API manufacture, formulation development, clinical trial supply, IXRS® technology (IVRS/IWRS) through to commercial-scale manufacture. The international company is a privately owned organization that has organically grown over 30 years and now employs in excess of 3,300 highly skilled personnel.  Almac is headquartered in Craigavon, Northern Ireland with US operations based in Pennsylvania, North Carolina and California.

To learn more about Almac please visit www.almacgroup.com, e-mail info@almacgroup.com or follow us on Twitter at https://twitter.com/AlmacGroup.

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